Randomised Double Blind Comparative Study of Efficacy and Tolerability of Telmisartan versus Enalapril in Patients of Stage 1 Essential Hypertension

1.Compare the efficacy and tolerability of telmisartan versus enalapril in patients of stage-1 essential hypertension, according to JNC 7 classification. 2.Compare safety with each drug in study group. Materials and Methods: The present study protocol was approved by IEC. The randomized study of 12 weeks from January to March 2013 conducted on 60 newly diagnosed stage 1 hypertensive patients in between 2065years of age. After taking written explained informed consent the patients are allocated into 2 groups. Group A (n = 30) were given Telmisartan 40mg Once Daily morning dose and Group B (n = 30) were given. Enalapril 10mg Once Daily morning dose. Complete blood picture, serum creatinine, blood urea, SGOT, SGPT urine analysis, ECG of all patients recorded at 0 and 12 weeks of study. Blood pressure was recorded at 0th, 4th, 8th, 12th weeks of study in sitting, standing and supine positions, mean of three taken for comparison. Results: Fall in systolic blood pressure(SBP) and diastolic blood pressure(DBP) was observed in both groups after completion of study. But Mean systolic blood pressure after completion of the study in group A and group B are 126.66±2.59 and 126.46±2.60 respectively, with no significant difference (p>0.05). Mean diastolic blood pressure after completion of the study in group A and group B are 79.2±1.12 and 79.33±0.95 respectively, with no significant difference (p>0.05).Dry cough was seen in 30% of group B patients, which is significant. Conclusion: In the 2 groups the 2 drugs are found to be equally effective in the reduction of SBP and DBP .In group B patients dry cough was significant side effect noticed.